The regenerative dentistry market is anticipated to grow from US$ 2.32 billion in 2024 and is projected to reach US$ 4.72 billion by 2031; it is expected to register a CAGR of 10.8% during 2025-2031. The rising prevalence of dental disorders, soaring aging population, and surging demand for cosmetic dentistry are contributing to the growing regenerative dentistry market size. However, the high-cost barriers in dental regeneration treatment hampers the regenerative dentistry market growth. Further, increased adoption of tissue regeneration is expected to bring in new regenerative dentistry market trends in the coming years.

In terms of revenue, North America dominated the market in 2024. It is estimated to dominate the global market during the forecast period. The US is the largest market for regenerative dentistry in the world.

Cavities and gum disease are one of the most preventable public health challenges in the US. According to the Centers for Disease Control and Prevention (CDC), more than 90% of adults aged 20 to 64 have experienced at least one cavity in their lifetime, and nearly 21% of this same age group had one or more untreated decayed permanent teeth in 2024. The situation is concerning among children as well, with more than half (52%) of those aged 6 to 8 having encountered cavities in their primary teeth. Additionally, nearly 47% of adults aged 30 and older exhibit signs of gum disease, a condition that becomes more common as individuals age. As per the American Dental Association (2020), ~5 million people aged 65-74 is edentulous in the country.

The adoption of technologies such as stem cell therapies and tissue engineering in regenerative dentistry in the US is transforming how dentists approach tooth repair, tissue regeneration, and the possibilities of whole-tooth engineering. Numerous phase I and II clinical trials conducted in the US and internationally have shown the safety and initial effectiveness of stem cell-based dental regenerative procedures. However, many of these studies involve small sample sizes and have short follow-up periods, highlighting the necessity for larger, multicenter trials. For instance, studies involving autologous dental pulp stem cells (DPSCs) combined with collagen scaffolds have reported positive pulp vitality responses and radiographic evidence of root maturation in immature permanent teeth. Likewise, clinical applications of SCAP-loaded hydrogels have demonstrated revascularization and apical closure in necrotic teeth. Thus, the increasing incidence of oral diseases and ongoing research initiatives are promoting the adoption of regenerative technologies in the US.

Regenerative Dentistry Market Analysis

Strategic Initiatives by Market Players to Provide Market Opportunities in Future

Companies operating in the regenerative dentistry market constantly focus on strategic developments such as product approvals, collaborations, funding, agreements, and new product launches, which help them improve their sales, increase their geographic reach, and reinforce their capacities to cater to a greater than existing customer base. A few strategic initiatives by key players operating in the regenerative dentistry market are mentioned below.

- In July 2024, Dentsply Sirona renewed its Symbios Allograft product line with a focus on the highest level of sterility and versatility.

- In February 2024, BioHorizons Camlog launched Striate+, an innovative collagen membrane for advanced bone and tissue regeneration, developed by Orthocell. The launch is part of the two companies' global distribution and manufacturing agreement.

- In April 2023, ZimVie Inc. launched two additions to its biomaterial's portfolio: the RegenerOss CC Allograft Particulate, a natural blend of cortical and cancellous bone particles that can be used to fill bony voids in a type of dental application, and the RegenerOss Bone Graft Plug, an easy-to-use grafting solution for filling extraction sockets and periodontal defects.

- In June 2022, VideaHealth announced that Health Canada had given it a Medical Device Establishment License for their AI-powered dental caries detection system, Video Caries Assist. VideaHealth's AI and software solutions were designed with efficiency and ethics in mind. They enable dentists to examine patient X-rays more successfully, get paid faster, and make more precise treatment suggestions.

Therefore, product launches, approvals, and collaborations are expected to create ample opportunities for the growth of the regenerative dentistry market in the coming years.

Regenerative Dentistry Market Report Segmentation Analysis

Key segments that contributed to the derivation of the regenerative dentistry market analysis are equipment and end user.

- Based on type, the regenerative dentistry market is segmented into natural biomaterials and synthetic biomaterials. The natural biomaterials segment held the largest share of the market in 2024.

- By technology, the market is divided into tissue engineering, stem cell therapy, and others. The tissue engineering segment held the largest share of the market in 2024.

- Per application, the regenerative dentistry market is categorized into periodontal regeneration, endodontic regeneration, tooth reconstruction, bone regeneration, and others. The periodontal regeneration segment held the largest share of the market in 2024.

- Based on age group, the regenerative dentistry market is bifurcated into pediatric and adult. The adult segment held a larger share of the market in 2024.

- By end user, the regenerative dentistry market is categorized into hospitals, dental clinics, and others. The dental clinics segment dominated the market in 2024.

Regenerative Dentistry Market: Competitive Landscape and Key Developments

Dentsply Sirona, Geistlich Pharma AG, Evonik Industries AG, ZimVie Inc., 3M, BioHorizons, Inc., Nobel Biocare, UBGEN Srl, B. & B. Dental S.r.l, Botiss Biomaterials GmbH, and Envista Holdings Corporation are among the key companies operating in the regenerative dentistry market.

The World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), Canadian Dental Care Plan (CDCP), Universal Catalogue of Health Services (CAUSES), National Medical Products Administration of China, Public Health Foundation of India (PHFI), and Australian Dental Research Foundation (ADRF) are among the primary and secondary sources referred to while preparing the regenerative dentistry market report.