Human Serum Albumin Segment, by Source to Account Largest Share in Natural Albumin Market during 2025-2031

According to our new research study on "Natural Albumin Market Forecast to 2031 - Global Analysis - by Source, Application, and End User," the market was valued at US$ 5.66 billion in 2024 to US$ 8.46 billion by 2031; the market is expected to register a CAGR of 6.0% during 2025-2031. The increasing hypoalbuminemia in chronic liver diseases, expanding applications in critical care and surgery, advancements in plasma fractionation technologies, and blood collection infrastructure.

The critical role of natural albumin in critical care settings and surgical procedures is a significant market driver. Albumin is widely used for plasma volume expansion, maintaining oncotic pressure, and drug delivery in patients experiencing shock, trauma, or undergoing extensive surgeries. For example, in 2022, the European Society of Intensive Care Medicine (ESICM) updated its guidelines, reinforcing the use of albumin in specific indications for septic shock patients, citing its benefits in hemodynamics and organ perfusion. Data from the National Health Service (NHS) in the UK indicated a consistent demand for albumin in intensive care units throughout 2023, particularly for patients with severe sepsis and burns. The American College of Surgeons (ACS) in their 2024 surgical guidelines emphasized the importance of maintaining adequate oncotic pressure during major abdominal surgeries to prevent complications like ascites and edema, thereby increasing the perioperative use of albumin. Furthermore, the development of new albumin-based drug delivery systems, such as those being explored for oncology treatments, expands its therapeutic utility beyond traditional applications. These advancements, coupled with the increasing number of complex surgical procedures globally, solidify albumin's indispensable role in modern medicine.

Based on source, the natural albumin market is segmented into human serum albumin, bovine serum albumin, and plant serum albumin. The human serum albumin segment held a largest natural albumin market share in 2024. Human serum albumin dominates due to its extensive use in critical care, liver support, and fluid management. Its high biocompatibility and clinical acceptance continue to drive demand across healthcare systems.

Based on applications, the natural albumin market is categorized into therapeutic applications, drug delivery, disease diagnostics, research, and other applications. The therapeutic applications segment held a significant share in 2024. Therapeutic applications include treatment of liver and kidney diseases, surgery support, hypovolemia, and hypoalbuminemia. Therapeutic use remains the largest segment, driven by rising incidences of liver disease, kidney disorders, and surgical needs. Its role in treating hypovolemia and hypoalbuminemia ensures consistent clinical demand.

Based on end users, the natural albumin market is divided into hospitals and clinics, pharmaceutical and biotechnological companies, research institutes, diagnostic laboratories, home care settings, and other end users. The hospitals and clinics segment held the largest natural albumin market share in 2024. Hospitals lead demand due to high utilization of albumin in emergency care, surgeries, and chronic disease management. Continued rise in patient volume and critical-care procedures supports this dominance.

CSL Ltd, Grifols SA, Taibang Bio Group Co. Ltd., Merck KGaA, Octapharma AG, HiMedia Laboratories Pvt Ltd, Takeda Pharmaceutical Co Ltd, Biotest AG., Lee BioSolutions, and Sartorius AG are among the leading companies operating in the global Natural Albumin Market.

Companies operating in the Natural Albumin Market adopt various organic and inorganic strategies. Organic strategies mainly include product launches and product approvals. Acquisitions, collaborations, and partnerships are among the inorganic growth strategies witnessed in the Natural Albumin Market. These growth strategies allow the market players to expand their businesses and enhance their geographic presence, thereby contributing to the overall Natural Albumin Market growth. Further, acquisition and partnership strategies help them strengthen their customer base and expand their product portfolios.

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