Protein Expression Market Size, Trends and Growth Analysis by 2027

The global protein expression market is projected to grow significantly, reaching approximately US$ 4,000.67 million by 2028, up from US$ 2,221.73 million in 2021. This growth represents a compound annual growth rate (CAGR) of 8.8% from 2021 to 2028.

Several key factors are driving this market expansion, including the rising prevalence of chronic diseases, an increasing elderly population, and a growing demand for protein biologics. Additionally, emerging economies are expected to present substantial growth opportunities for market participants.

Protein expression refers to the process through which proteins are synthesized, modified, and regulated. This process encompasses various laboratory techniques and procedures that facilitate the production of proteins. It enables the generation and purification of specific proteins, either within living cells or in vitro. The proteins produced through these techniques can be utilized in industrial applications or for the diagnosis and treatment of diseases. Furthermore, protein expression provides essential substrates or enzymes necessary for subsequent analyses.

Advancements in technology have led to a greater adoption of molecular biology techniques aimed at developing therapeutic solutions. Many of these therapeutic approaches leverage genomic and transcriptomic data, which aid in identifying biomarkers for disease monitoring and risk prediction. The rise of personalized or precision medicine has been significant, driven by an increased understanding of genetic diversity among individuals. For example, mRNA-mediated therapies are now employed to treat various conditions, characterized by reduced immunogenicity, enhanced translation efficiency, improved stability, pharmaceutical safety, and transient protein expression, as only the mRNA is modified without altering the host genome.

Moreover, the pharmaceutical and biotechnology sectors have innovated numerous techniques to address cancer and neurodegenerative diseases. The transient gene expression method has led to notable advancements in research concerning neurotrauma and neurodegenerative disorders, paving the way for precision medicine tailored to these ailments. Technological progress in epigenetics, genetics, and proteomics is also facilitating the development of treatments for a range of genetic disorders, including both single and multiple cell disorders.

The Precision Medicine Initiative, launched in the United States in 2015, has significantly promoted the application of genetic engineering, genomics, and proteomics, thereby enhancing the utilization of protein expression techniques. Consequently, ongoing research and development efforts, along with increasing government initiatives to support precision medicine, are driving the adoption of protein expression methodologies.

The protein expression market is categorized by product type into instruments, reagents, expression vectors, and competent cells. In 2021, the reagents segment dominated the market, and it is anticipated to exhibit the highest CAGR of 9.5% during the forecast period.

When considering services, the protein expression market is divided into antibody development and production, protein expression and production, hybridoma one-stop services, stable cell line development, and bioanalytical assay services. The antibody development and production segment held the largest market share in 2021 and is projected to achieve the highest CAGR of 9.7% throughout the forecast period.

In terms of application, the market is segmented into research, therapeutic, and industrial applications. The therapeutic segment was the largest in 2021 and is expected to maintain this trend with a projected CAGR of 9.4% during the forecast period.

From the perspective of end users, the protein expression market is classified into pharmaceutical and biotechnology companies, academic research institutions, and contract research organizations. The pharmaceutical and biotechnology companies segment accounted for the largest share in 2021 and is forecasted to grow at the highest CAGR of 5.6% in the coming years.

Key secondary sources referenced in the preparation of the report on the protein expression market include the Central Drugs Standard Control Organization, the Commission for Protection against Health Risks, various contract research organizations, and the Drug Safety and Effectiveness Network.